Aluminium toxicosis: a review of toxic actions and effects
Aluminium toxicosis: a review of toxic actions and effects
Publication Year:
2019
Authors:
Igbokwe, Ikechukwu Onyebuchi; Igwenagu, Ephraim; Igbokwe, Nanacha Afifi
Language:
English
Resource Type:
Journal Article
Summary:
Exposure to Aluminium (Al) occurs through inhalation, ingestion, and skin contact, leading to health concerns such as oxidative stress, neurological disorders, and heart issues. This review underscores the diverse health implications of Al, advocating for continuous research on its public health impact.
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Resource Information
Abstract
Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn’s disease, inflammatory bowel diseases, anemia, Alzheimer’s disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance.
Resource Type
Journal Article
Publication Year
2019
Author
Igbokwe, Ikechukwu Onyebuchi; Igwenagu, Ephraim; Igbokwe, Nanacha Afifi
Language
English
Specific Contaminants
Other Chemicals, Aluminum
University Affiliation
University of Maiduguri
Business Connect Takeaways
Telemedicine, which involves the use of technology to provide healthcare services remotely, has the potential to improve the management of diabetes by increasing access to care, improving patient engagement, and reducing healthcare costs.
The use of telemedicine in diabetes management has been shown to be effective in improving glycemic control, reducing hospitalizations, and increasing patient satisfaction. However, the effectiveness of telemedicine may depend on factors such as patient characteristics, the type of technology used, and the quality of care provided.
The article provides an overview of the current state of telemedicine in diabetes management, including the types of telemedicine interventions available, the evidence supporting their use, and the barriers to their implementation. The article also discusses the regulatory and reimbursement issues related to telemedicine and provides recommendations for future research and policy development. The article emphasizes the need for further research to evaluate the long-term effectiveness and cost-effectiveness of telemedicine in diabetes management and to address the barriers to its implementation.