Aluminium toxicosis: a review of toxic actions and effects

Aluminium toxicosis: a review of toxic actions and effects

Publication Year:
Igbokwe, Ikechukwu Onyebuchi; Igwenagu, Ephraim; Igbokwe, Nanacha Afifi
Resource Type:
Journal Article
Exposure to Aluminium (Al) occurs through inhalation, ingestion, and skin contact, leading to health concerns such as oxidative stress, neurological disorders, and heart issues. This review underscores the diverse health implications of Al, advocating for continuous research on its public health impact.
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Resource Information


Aluminium (Al) is frequently accessible to animal and human populations to the extent that intoxications may occur. Intake of Al is by inhalation of aerosols or particles, ingestion of food, water and medicaments, skin contact, vaccination, dialysis and infusions. Toxic actions of Al induce oxidative stress, immunologic alterations, genotoxicity, pro-inflammatory effect, peptide denaturation or transformation, enzymatic dysfunction, metabolic derangement, amyloidogenesis, membrane perturbation, iron dyshomeostasis, apoptosis, necrosis and dysplasia. The pathological conditions associated with Al toxicosis are desquamative interstitial pneumonia, pulmonary alveolar proteinosis, granulomas, granulomatosis and fibrosis, toxic myocarditis, thrombosis and ischemic stroke, granulomatous enteritis, Crohn’s disease, inflammatory bowel diseases, anemia, Alzheimer’s disease, dementia, sclerosis, autism, macrophagic myofasciitis, osteomalacia, oligospermia and infertility, hepatorenal disease, breast cancer and cyst, pancreatitis, pancreatic necrosis and diabetes mellitus. The review provides a broad overview of Al toxicosis as a background for sustained investigations of the toxicology of Al compounds of public health importance.

Resource Type

Journal Article

Publication Year



Igbokwe, Ikechukwu Onyebuchi; Igwenagu, Ephraim; Igbokwe, Nanacha Afifi



Specific Contaminants

Other Chemicals, Aluminum

University Affiliation

University of Maiduguri

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