In response to a 2015 cholera outbreak in Tanzania, where vendors supplied inadequately chlorinated water, the Tanzanian Ministry of Health and UNICEF trained vendors to use chlorine tablets, with CDC’s support. Three months post-intervention, chlorine was found in 69.6% of water tanks, but only 17.4% met adequate levels. This indicates high tablet acceptance but suggests adjusted dosing for future. Chlorine tablets provide a community-level solution for safer water.