Drinking water quality is one of the greatest factors affecting human health. However, drinking water quality in many countries, especially in developing countries is not desirable and poor drinking water quality has induced many waterborne diseases. This special issue of Exposure and Health was edited to gain a better understanding of the impacts of drinking water quality on public health so that proper actions can be taken to improve the drinking water quality conditions in many countries. This editorial introduction reviewed some latest research on drinking water quality and public health, summarized briefly the main points of each contribution in this issue, and then some research fields/directions were proposed to boost further scientific research in drinking water quality and public health. The papers in this issue are interesting and cover many aspects of this research topic, and will be meaningful for the sustainable drinking water quality protection.