This study is an analysis from the SHINE trial, a community-based, cluster-randomized, 2×2 factorial trial conducted in rural Zimbabwe. The trial evaluated the effects of two interventions: a Water, Sanitation, and Hygiene (WASH) package and an Infant and Young Child Feeding (IYCF) program. The WASH intervention included the provision of improved pit latrines, handwashing stations with liquid soap, point-of-use water chlorination, and the creation of clean child play spaces. The IYCF intervention focused on enhancing infant feeding practices to improve child health and development. The main outcomes measured were the molecularly detected prevalence and quantity of 29 different enteric pathogens in children's stool samples, collected at several timepoints throughout infancy and during diarrheal episodes. The study found that the WASH intervention led to only a small reduction in the burden of parasitic infections, with no measurable impact on bacterial or viral pathogen levels. Similarly, the IYCF intervention did not reduce the burden of enteric infections. Moreover, neither intervention resulted in a decrease in the incidence of pathogen-attributable diarrhea. These findings suggest that the standard household-level WASH improvements implemented in the SHINE trial were not sufficient to interrupt fecal–oral transmission in a highly contaminated rural environment. The results highlight the need for more transformative and comprehensive WASH solutions that can more effectively reduce exposure to enteric pathogens in such settings.